First-trimester screening for pre-eclampsia

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First-trimester screening for pre-eclampsia: moving from personalized risk prediction to prevention.

Maternal gestational hypertensive disorders and their complications have ranked consistently as the primary cause of adverse maternal and neonatal outcome since the institution of prenatal care1. The recognition of predisposing circumstances, such as nulliparity, familial disposition, prior pre-eclampsia, renal disease, hypertension and diabetes, reaches back as far as four centuries. In 1984, ...

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Prediction and prevention of early-onset pre-eclampsia: impact of aspirin after first-trimester screening.

OBJECTIVE To examine the effect of a combination of screening and treatment with low-dose aspirin on the prevalence of early-onset pre-eclampsia (PE). METHODS This was a retrospective analysis of two consecutive cohorts of women screened for early PE. The first cohort was observed to determine whether algorithms developed to screen for PE at 11 to 13 + 6 weeks' gestation could be applied to o...

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A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound.

OBJECTIVE To investigate the value of maternal serum placental protein 13 (PP-13) measurement and uterine artery Doppler during first-trimester screening in the prediction of early pre-eclampsia. METHODS This was a nested case-control prospective study of pregnancies at 11 + 0 to 13 + 6 weeks of gestation. The pulsatility index (PI) of blood flow in the uterine arteries and the maternal serum...

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Screening for pre-eclampsia in the first trimester: role of maternal hemodynamics and bioimpedance in non-obese patients.

OBJECTIVE To test if maternal hemodynamics and bioimpedance, assessed at the time of combined screening for PE, are able to identify in the first trimester of gestation normotensive non-obese patients at risk for pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR). METHODS One hundred and fifty healthy nulliparous non-obese women (body mass index < 30 kg/m2 ) in the first trimest...

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Economic assessment of screening for pre-eclampsia.

BACKGROUND Pre-eclampsia is a major contributor to maternal and neonatal morbidity and mortality. Our objectives in this study are to economically assess, from the payer perspective, routine screening for pre-eclampsia using placental markers -placental protein 13 and placental growth factor - and uterine artery Doppler compared with standard care. METHODS A decision model was developed, whic...

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ژورنال

عنوان ژورنال: Ultrasound in Obstetrics and Gynecology

سال: 2005

ISSN: 0960-7692

DOI: 10.1002/uog.2591